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This paper introduces the Adaptive Stakeholders’ Interface Management System (ASIMS) for university infrastructure projects, employing a system-of-systems approach. A mixed-methods design – involving surveys, flowcharting, key informant discussions, descriptive and inferential analyses – was adopted. ASIMS targeted 412 project management professionals with ≥ 10 years’ experience across 12 universities. These experts provided perspectives that informed ASIMS development. The system was then deployed in two ongoing projects at the Federal University of Technology Owerri (a hold-out sample) and validated through performance feedback from 10 experts. Findings reveal that ASIMS significantly improves project communication by increasing openness (19.1%), honesty (9.3%), inclusivity (5.3%), and transparency (3.5%). It also leads to reductions in: conflicts (17.2%), uncertainties (13.5%), cost overruns (11.2%), time overruns (10.6%), and quality compromises (7.8%). In conclusion, ASIMS promotes communication, inclusivity, collaboration, and conflict resolution. Adoption of Agile principles that emphasize continuous multi-level stakeholder engagement, communication, and accountability is recommended to optimise interface management.